PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
Work
Year: 2012
Type: article
Abstract: Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive inherited Parkinson's disease (PD). We have exploited our recent discovery that recombinant insect PINK1 is catalytically ... more
Source: Open Biology
Authors Chandana Kondapalli, Agne Kazlauskaite, Ning Zhang, Helen I. Woodroof, David G. Campbell +8 more
Institutions University of Dundee, MRC Protein Phosphorylation and Ubiquitylation Unit, The Honourable Society of Lincoln's Inn, Cancer Research UK
Cites: 43
Cited by: 862
Related to: 10
FWCI: 36.43
Citation percentile (by year/subfield): 99.99
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Sustainable Development Goal Good health and well-being
Open Access status: green